Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the Mtb DprE1-C387S mutant, with minimal inhibitory concentrations (MIC90) of 0.9 µM for H37Rv and MoxR strains, and 0.5 µM for the DprE1-P116S strain.
Molecular Weight:
475.34
Formula:
C20H15F6N3O4
Target:
Others
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