JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM for TYK2, 7.7 nM for JAK1, and 629.6 nM for JAK3. Moreover, JAK-IN-27 impedes IFN-alpha2B-induced phosphorylation of STAT3 in Jurkat cells with an IC50 of 23.7 nM.
Molecular Weight:
413.42
CAS Number:
[2673176-36-6]
Formula:
C20H21F2N7O
Target:
JAK
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