18-hydroxy-11-deoxy Corticosterone, CAS [[379-68-0]] Preis auf Anfrage

Product Overview

• Article Name: 18-hydroxy-11-deoxy Corticosterone, CAS [[379-68-0]] Preis auf Anfrage
• Biozol Catalog Number: BYT-ORB2283106
• Supplier Catalog Number: orb2283106
• Alternative Catalog Number: BYT-ORB2283106-10,BYT-ORB2283106-50
• Manufacturer: Biorbyt
• Category: Biochemikalien

Product Description

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands capsular portion. Its continuous infusion (200 µg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

Product Properties

• Molecular Weight: 346.46
• CAS Number: [379-68-0]
• Formula: C21H30O4
• Target: Others