KH-4-43 is a potent and selective inhibitor of the CRL4 E3 ubiquitin ligase complex, binding its ROC1-CUL4A core with high affinity (Kd = 83 nM). This small molecule is a valuable research tool for investigating CRL4 function in cancer biology and has demonstrated anticancer activity in cellular assays.
Molecular Weight:
422.74
CAS Number:
[2813310-07-3]
Formula:
C19H10ClF3N2O4
Target:
E1/E2/E3 Enzyme,Others
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