Sesaminol is an orally active Nrf2-ARE pathway activator that promotes Nrf2 nuclear translocation and upregulates antioxidant enzymes like NQO1. It demonstrates neuroprotective effects in cellular models, such as inhibiting 6-OHDA-induced ROS and apoptosis in SH-SY5Y cells, and in vivo against rotenone-induced Parkinsons pathology.
Molecular Weight:
370.35
CAS Number:
[74061-79-3]
Formula:
C20H18O7
Target:
Nrf2,Reactive Oxygen Species
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