YT 6-2-PEG3-C2-NH2 is a key component in constructing the AUTOTAC degrader ATC-324, which targets the androgen receptor (AR) for autophagic degradation via the p62/SQSTM1 pathway. This mechanism, validated in prostate cancer research models, effectively reduces nuclear AR levels and suppresses the expression of AR and its splice variant AR-v7.
Molecular Weight:
634.71
Formula:
C33H44F2N2O8
Target:
AUTACs,PROTACs
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