Adekalant (H 345/52) is a selective I(Kr) channel blocker with minimal proarrhythmic risk, effectively delaying cardiac repolarization by inhibiting HERG currents (IC50 230 nM). Its favorable safety profile, characterized by reduced dispersion and absence of TdP induction, makes it a valuable research tool for in vitro and in vivo studies of arrhythmia mechanisms and antiarrhythmic drug development.
Molecular Weight:
401.5
CAS Number:
[227940-00-3]
Formula:
C22H31N3O4
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