Givinostat, CAS [[497833-27-9]]

Product Overview

• Article Name: Givinostat, CAS [[497833-27-9]]
• Biozol Catalog Number: BYT-ORB3027338
• Supplier Catalog Number: orb3027338
• Alternative Catalog Number: BYT-ORB3027338-1, BYT-ORB3027338-1, BYT-ORB3027338-10, BYT-ORB3027338-100, BYT-ORB3027338-25, BYT-ORB3027338-5, BYT-ORB3027338-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: ITF-2357, ITF2357, Givinostat

Product Description

Givinostat (ITF-2357) is an orally bioavailable, pan-HDAC inhibitor that blocks STAT5 phosphorylation, demonstrating antitumor effects in crlf2-rearranged BCP-ALL models. Its anti-inflammatory properties, including suppression of TNF-alpha and IL-1beta, and promotion of beta-cell survival support research in leukemia, diabetes, and arthritis, as evidenced by in vitro and in vivo studies.

Product Properties

• Molecular Weight: 421.5
• Purity: 98.56% (May vary between batches)
• CAS Number: [497833-27-9]
• Formula: C24H27N3O4
• Target: STAT,IL Receptor,TNF,Apoptosis,HDAC

Application Notes

• Application Notes: Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:4 mg/mL (9.49 mM),DMSO:160 mg/mL (379.6 mM)