SM875 is a degrader specifically targeting the cellular prion protein (PrP) with an IC50 of 7.87 µM. By binding to the folding intermediates of PrP, SM875 facilitates their degradation via the autophagy-lysosome pathway. It acts exclusively on nascent, immature PrP molecules and does not affect mature PrP synthesized beforehand. SM875 has the potential to inhibit prion replication, making it a promising compound for research in neurodegenerative diseases, particularly prion diseases.
Molecular Weight:
414.25
CAS Number:
[919023-94-2]
Formula:
C19H16BrN3O3
Target:
Others
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