EGFR-IN-158 (compound 12e) is an orally active EGFR inhibitor with an IC50 value of 0.22 nM for EGFR (Del19/T790M). By binding to EGFR, EGFR-IN-158 inhibits phosphorylation and downstream signaling, thereby suppressing the proliferation of tumor cell lines and promoting apoptosis.
Formula:
C27H35ClN8O4S
Target:
EGFR,Apoptosis
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