EGFR-IN-150, CAS [[3037323-16-0]] Preis auf Anfrage

Product Overview

• Article Name: EGFR-IN-150, CAS [[3037323-16-0]] Preis auf Anfrage
• Biozol Catalog Number: BYT-ORB3028683
• Supplier Catalog Number: orb3028683
• Alternative Catalog Number: BYT-ORB3028683-10, BYT-ORB3028683-50
• Manufacturer: Biorbyt
• Category: Biochemikalien

Product Description

EGFR-IN-150 is an EGFR inhibitor that effectively inhibits the phosphorylation of mutant epidermal growth factor receptor (EGFR) and its downstream AKT signaling pathway, exerting antitumor effects and inducing HMOX1 expression to trigger ferroptosis. This compound exhibits an IC50 of 0.386 µM against the non-small cell lung cancer (NSCLC) cell line H1975 and significantly suppresses the colony formation and migration abilities of H1975 and A549 cells, while also inducing apoptosis. Additionally, EGFR-IN-150 prominently reduces tumor growth in H1975 tumor-bearing mouse CDX models. It holds promise for research related to non-small cell lung cancer.

Product Properties

• Molecular Weight: 522.985
• CAS Number: [3037323-16-0]
• Formula: C29H23ClN6O2
• Target: EGFR,Apoptosis