JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
Molecular Weight:
365.379
CAS Number:
[1802937-26-3]
Formula:
C21H19NO5
Target:
FAK,Src
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