CTSLCTSB-IN-1 (Compound212-148) is a dual-specificity inhibitor targeting the host virus spike cleavage proteins CTSL/CTSB and TMPRSS2, with IC50 values of 2.13/64.07 nM and 1.38 µM, respectively. By inhibiting the cleavage of viral spike proteins, CTSLCTSB-IN-1 obstructs two critical entry pathways of the SARS-CoV-2 virus, making it useful for anti-SARS-CoV-2 research.
Formula:
C41H47N7O6S
Target:
Cysteine Protease,SARS-CoV
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