PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor aimed at PARP7 and HDAC, exhibiting antitumor properties. It demonstrates inhibition of various PARPs and HDACs with IC50 values of 83.3 nM for PARP1, 3.1 nM for PARP7, 35 nM for HDAC1, 30.3 nM for HDAC2, 35.4 nM for HDAC3, and 6.4 nM for HDAC6.
Formula:
C29H33F3N8O6
Target:
PARP,HDAC
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