PROTACGSK-3beta Degrader-1 (compound 1) is a degrader targeting GSK-3beta with an IC50 of 833 nM. This compound consists of SB-216763 (a GSK-3beta inhibitor), a PEG linker, and CRBN (E3 ligase ligand). It reduces neurotoxicity induced by Abeta25-35 peptide and CuSO4 and is applicable in Alzheimers disease research.
Formula:
C43H42Cl2N6O9
Target:
PROTACs,GSK-3
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