Antileishmanial agent-27 (compound 7j) is a benzothiazole-coumarin derivative. It acts as a competitive inhibitor of arginyl-tRNA synthetase (ArgRS). This compound demonstrates selectivity towards the Leishmania donovani ArgRS (LdArgRS) over the human counterpart (HsArgRS), with IC50 values of 1.2 µM and 19 µM, respectively. Additionally, Antileishmanial agent-27 exhibits favorable pharmacokinetic properties.
Formula:
C24H16BrNO3S2
Target:
Parasite
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