3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. It enhances the expression of glucose transporter 1 (GLUT1) and inhibits topoisomerase I/II activity. Additionally, 3-Fluoro-evodiamine glucose induces apoptosis and causes cell cycle arrest at the G2/M phase. This compound demonstrates anti-tumor activity both in vivo and in vitro, with no significant toxicity observed.
Formula:
C25H26FN3O7
Target:
Apoptosis,Topoisomerase,transporter
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