IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC50 of 0.19 µM for PHD2. In acute myeloid leukemia (AML) cells, IOX5 can stabilize HIF-1alpha, inhibit cell proliferation, and induce apoptosis. It exhibits anti-leukemia activity.
Formula:
C17H19F3N4O2
Target:
HIF/HIF Prolyl-Hydroxylase,Apoptosis
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