NLRP3-IN-81, CAS [[2922814-85-3]] Preis auf Anfrage
Biozol Catalog Number:
BYT-ORB3135122
Supplier Catalog Number:
orb3135122
Alternative Catalog Number:
BYT-ORB3135122-10,BYT-ORB3135122-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 µM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1beta release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
