Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 µM). Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.
Molecular Weight:
435.39
CAS Number:
[3081450-95-2]
Formula:
C16H9Cl2KN2O2S2
Target:
NO Synthase,Piezo Channel
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