HW201877 is a potent, orally active inhibitor of 15-prostaglandin dehydrogenase (15-PGDH), with an IC50 value of 3.6 nM. It significantly increases PEG2 levels in A549 cells and demonstrates notable efficacy in animal models of tissue injury and fibrosis. HW201877 is utilized in research for inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), and Crohns disease (CD).
Molecular Weight:
440.45
CAS Number:
[2927452-83-1]
Formula:
C22H22F2N6O2
Target:
Dehydrogenase
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