PROTAC IRAK4 degrader-13, CAS [[2432992-21-5]] Preis auf Anfrage
Biozol Catalog Number:
BYT-ORB3136269
Supplier Catalog Number:
orb3136269
Alternative Catalog Number:
BYT-ORB3136269-10, BYT-ORB3136269-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
PROTACIRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader, demonstrating DC50 values of 0.86 nM and 1.1 nM in monocytes and lymphocytes within PBMCs, respectively. It significantly induces TIR signaling activation and inhibits the expression of circulating pro-inflammatory cytokines in a psoriasis mouse model induced by Imiquimod. PROTACIRAK4 degrader-13 is applicable in the study of neutrophilic inflammatory diseases driven by TLR and IL-1R, such as hidradenitis suppurativa (HS) and atopic dermatitis (AD).
Molecular Weight:
843.94
CAS Number:
[2432992-21-5]
Formula:
C44H52F3N9O5
Target:
Interleukin,IRAK,PROTACs,TLR
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