Adenosine receptor antagonist 6, CAS [[2913578-04-6]] Preis auf Anfrage
Biozol Catalog Number:
BYT-ORB3136376
Supplier Catalog Number:
orb3136376
Alternative Catalog Number:
BYT-ORB3136376-10, BYT-ORB3136376-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
Adenosine receptor antagonist 6 is an orally active, selective (S)-enantiomer compound that acts as an A2A adenosine receptor (A2AAR) antagonist. It binds to the A2A adenosine receptor with a Ki value of 19.18 nM. This antagonist inhibits cAMP production mediated by 5-N-ethylcarboxamide adenosine (NECA) with an IC50 value of 0.089 µM and reduces immunosuppression, while enhancing the secretion of IL-2 and IFN-gamma. It counteracts adenosine-induced immunosuppression in T cell activation and cytokine release and inhibits tumor growth in CT26/MC38 xenograft models, making it applicable for colorectal cancer research.
