Its been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Application Notes: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 101.9 kDa. The protein migrates as 115-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation
SARS-CoV-2 (COVID-19) S1 protein.
Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of of SARS-CoV-2 (COVID-19) S1 protein.
Flow cytometric analysis of Vero E6 cells using SARS-CoV-2 (COVID-19) S1 protein.
Flow cytometric analysis of Vero E6 cells using SARS-CoV-2 (COVID-19) S1 protein.
Flow cytometric analysis of Vero E6 cells using SARS-CoV-2 (COVID-19) S1 protein.
SDS-page analysis of SARS-CoV-2 (COVID-19) S1 protein.
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