Interleukin 33, Nuclear factor from high endothelial venules, NFHEV, Chromosone 9 open reading frame 26, C9ORF26, Interleukin-1 family member 11, IL-1F11.
Interleukin 33 (IL-33) is a proimflammatory cytokine belonging to the IL-1 family. IL-33 is cleaved in vivo, generating an N terminal and a C terminal fragment. The C terminal fragment corresponds to the mature IL-33 protein and mediates its biological effect by interacting with the IL-1 receptor, also known as ST2. Binding of mature IL-33 to this receptor activates NF-kappaB and MAP kinases and induces the production of associated cytokines in particular IL-4, IL-5 and IL-13 causing severe pathological changes in mucosal organs
