CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.
Clonality:
Polyclonal
Concentration:
1 mg/ml
Molecular Weight:
28+35kD
Application Dilute:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Western Blot analysis of various cells using Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody diluted at 1:1000
Western Blot analysis of HeLa cells using Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody diluted at 1:1000
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HeLa cells, treated with Etoposide 25uM 60, using Caspase 6 (Cleaved-Asp162) Antibody. The lane on the right is blocked with the synthesized peptide.
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