FRS2 (phospho Tyr436) rabbit pAb, Rabbit, Polyclonal

Product Overview

• Article Name: FRS2 (phospho Tyr436) rabbit pAb, Rabbit, Polyclonal
• Biozol Catalog Number: EBT-ES1496
• Supplier Catalog Number: ES1496
• Alternative Catalog Number: EBT-ES1496-50, EBT-ES1496-100
• Manufacturer: ELK Biotechnology
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, IHC, WB
• Species Reactivity: Human, Monkey, Mouse
• Immunogen: The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436. AA range:402-451
• Alternative Names: FRS2, Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1

Product Description

function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

Product Properties

• Clonality: Polyclonal
• Concentration: 1 mg/ml
• Molecular Weight: 65kD
• NCBI: 10818
• UniProt: Q8WU20

Application Notes

• Application Dilute: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Images

Western Blot analysis of various cells using Phospho-FRS2 (Y436) Polyclonal Antibody

Western Blot analysis of COS cells using Phospho-FRS2 (Y436) Polyclonal Antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using FRS2 (Phospho-Tyr436) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot analysis of lysates from COS7 cells , using FRS2 (Phospho-Tyr436) Antibody. The lane on the right is blocked with the phospho peptide.