Synthesized peptide derived from human HSH2D AA range: 288-338
Alternative Names:
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR, MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008],
