The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008],
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Western Blot analysis of various cells using Actin alpha1 Polyclonal Antibody diluted at 1:500
Western Blot analysis of HEPG2-UV cells using Actin alpha1 Polyclonal Antibody diluted at 1:500
Immunohistochemistry analysis of paraffin-embedded human muscle tissue, using Actin-alpha-1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from rat muscle cells, using Actin-alpha-1 Antibody. The lane on the right is blocked with the synthesized peptide.
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