Synthesized peptide derived from human PPGB (20k, Cleaved-Met327)
Alternative Names:
Lysosomal protective protein (EC 3.4.16.5,Carboxypeptidase C,Carboxypeptidase L,Cathepsin A,Protective protein cathepsin A,PPCA,Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain, Lysosomal protective protein 20 kDa chain]
catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain, disulfide-linked.,
Immunohistochemical analysis of paraffin-embedded human uterus. 1, Antibody was diluted at 1:200(4 overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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