The antiserum was produced against synthesized peptide derived from the Internal region of human CD101. AA range:731-780
Alternative Names:
CD101, EWI101, IGSF2, V7, Immunoglobulin superfamily member 2, IgSF2, Cell surface glycoprotein V7, Glu-Trp-Ile EWI motif-containing protein 101, EWI-101, CD101
function:Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.,PTM:N-glycosylated.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.,
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Western Blot analysis of mouse brain cells using CD101 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody(catalog:RS0002) was diluted at 1:20000
Western Blot analysis of MOUSE-BRAIN cells using CD101 Polyclonal Antibody diluted at 1:1000. Secondary antibody(catalog:RS0002) was diluted at 1:20000
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