MLK3 rabbit pAb, Rabbit, Polyclonal

Product Overview

• Article Name: MLK3 rabbit pAb, Rabbit, Polyclonal
• Biozol Catalog Number: EBT-ES6252
• Supplier Catalog Number: ES6252
• Alternative Catalog Number: EBT-ES6252-50, EBT-ES6252-100
• Manufacturer: ELK Biotechnology
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, IHC
• Species Reactivity: Human, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from human MLK3. AA range:640-689
• Alternative Names: MAP3K11, MLK3, PTK1, SPRK, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase

Product Description

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],

Product Properties

• Clonality: Polyclonal
• Concentration: 1 mg/ml
• NCBI: 4296
• UniProt: Q16584

Application Notes

• Application Dilute: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Images

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MLK3 Antibody. The picture on the right is blocked with the synthesized peptide.