TRAP230 rabbit pAb, Rabbit, Polyclonal

Product Overview

• Article Name: TRAP230 rabbit pAb, Rabbit, Polyclonal
• Biozol Catalog Number: EBT-ES8147
• Supplier Catalog Number: ES8147
• Alternative Catalog Number: EBT-ES8147-50, EBT-ES8147-100
• Manufacturer: ELK Biotechnology
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from human MED12. AA range:611-660
• Alternative Names: MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230, Mediator of RNA polymerase II transcription subunit 12, Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45, Mediator complex subunit 12, OPA-containing prote

Product Description

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009],

Product Properties

• Clonality: Polyclonal
• Concentration: 1 mg/ml
• NCBI: 9968
• UniProt: Q93074

Application Notes

• Application Dilute: WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Images

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using MED12 Antibody. The picture on the right is blocked with the synthesized peptide.