ET Receptor Antagonist (PD 145065)

Product Overview

• Article Name: ET Receptor Antagonist (PD 145065)
• Biozol Catalog Number: ECH-331-18
• Supplier Catalog Number: 331-18
• Alternative Catalog Number: ECH-331-18-1MG, ECH-331-18-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 153049-49-1 Molecular Weight: 949.49 Salt Form: Na+ Purity: >96% Sequence (3-letter): Ac-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH Sequence (1-letter): Ac-(D-Bhg)LDIIW-OH Storage: -20 ?C or below Solubility: water, PBS and DMSO 1 mg/ml D-Bhg = D-5H-Dibenzo[a,d]cycloheptene-5-acetic acid ET Antagonist PD 145065 is used as an endothelin-A/endothelin-B (ETA/ETB) receptor antagonist. PD 145065 is also a growth factor that binds to G protein-coupled receptors and serves as a useful model to study mitogenic signal transduction by vasoactive peptides.

References

1. Kanagy, N.L. et al. (2001) ?Role of Endothelin in Intermittent Hypoxia-Induced Hypertension? 37 (2 Pt 2): 511-5. 2. Bourque, S.L. et al (2012) ?Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition? Br. J. Pharmacol. 165 (6): 1992-1999. 3. Dobrowolski, L. (2003) ?Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin? Acta Physiol. Scand. 159 (1): 7-13.

Application Notes

• Application Notes: Categories: Peptides. Related: Cardiovascular, Neuropeptides & Hormones. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature