Apamin, bee venom (SS1-11, SS3-15)

Product Overview

• Article Name: Apamin, bee venom (SS1-11, SS3-15)
• Biozol Catalog Number: ECH-425-10
• Supplier Catalog Number: 425-10
• Alternative Catalog Number: ECH-425-10-0.5MG, ECH-425-10-1MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 24345-16-2 Molecular Weight: 2029.93 Salt Form: Acetate Purity: >96% Sequence (3-letter): Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15) Sequence (1-letter): CNCKAPETALCARRCQQH-NH2 Storage: -20 ?C or below Solubility: water to 1 mg/mL Apamin is a peptide toxin found in bee venom that is known to cross the blood-brain barrier. Apamin potently blocks ATP-type Ca+2-activated K+ channels SK1, SK2 and SK3 (low nM to sub-nM IC50), but is inactive against SK4. Apamin is used to elucidate the roles of SK channels in neurons and some cancer cells. It is a globular peptide with disulfide bridges between Cys1-Cys11 (SS1-11) and Cys3-Cys15 (SS3-15).

References

1. Blatz, A.L. and Magleby, K.L. (1986) ?Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle? Nature 323: 718 ? 720. 2.Burnham, M.P. et al. (2002) ?Characterization of an apamin-sensitive small-conductance Ca2+-activated K+ channel in porcine coronary artery endothelium: relevance to EDHF? Br. J. Pharmacol. 135 (5): 1133?1143.

Application Notes

• Application Notes: Categories: Peptides. Related: Central Nervous System. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature