Spantide II

Product Overview

• Article Name: Spantide II
• Biozol Catalog Number: ECH-712-36
• Supplier Catalog Number: 712-36
• Alternative Catalog Number: ECH-712-36-1MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 129176-97-2 Molecular Weight: 1667.7 Salt Form: TFA Purity: >96% Sequence (3-letter): e-nicotinoyl-D-Lys-Pro-3Pal-Pro-(3,4Cl)D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2 (3Pal = 3-pyridylalanine) Sequence (1-letter): (e-nicotinoyl)kP(3Pal)P((3,4Cl)D)FNwFwL(Nle)-NH2 Storage: -20 ?C or below Solubility: water (1 mg/mL) Spantide II is an undecapeptide substance P (SP) analog that is more potent as a substance P antagonist than spantide I and less effective in releasing histamine from mast cells. It is a neurokinin-1 receptor (NK-1R) antagonist that is used to control inflammation, particularly in skin conditions, and has negligible neurotoxicity.

References

1. Hakanson, R. et al. (1990) ?Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect? Regul. Pept. 31 (1): 75-82. 2.Kincy-Cain, T. and Bost, K.L. (1996) ?Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II? J. Immunol. 157 (1): 255-264. 3. Gerfen, C.R. (1991) ?Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain? Brain Res. 556 (1): 165?170.

Application Notes

• Application Notes: Categories: Peptides. Related: Neuropeptides & Hormones. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature