Furin Inhibitor II

Product Overview

• Article Name: Furin Inhibitor II
• Biozol Catalog Number: ECH-855-10
• Supplier Catalog Number: 855-10
• Alternative Catalog Number: ECH-855-10-1MG,ECH-855-10-25MG,ECH-855-10-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: ?673202-67-0 Molecular Weight: 953.63 Salt Form: TFA Purity: >96% Sequence (3-letter): D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 Sequence (1-letter): rrrrrr-NH2 Storage: -20 ?C or below Solubility: 20% acetonitrile/water 1 mg/mL Furin inhibitor II, as the name implies, inhibits furin (Ki = 0.106 for purified furin). Furin is an enzyme belonging to the subtilisin-like proprotein convertase family which process precursor proteins into biologically active products. Representative substrates include von Willebrand factor, TGF?-1 precursor, MMP-1, gp160, proparathyroid hormone and proalbumin. Peptide contains all D-amino acids, also called Hexa-D-Arg or Hexa-D-Arginine or (D-Arg)6-NH2

References

1.Cameron, A. et al. (2000) ?Polyarginines Are Potent Furin Inhibitors? J. Biol. Chem. 275: 36741-36749. 2.Henrich, S. et al. (2005) ?Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificity? J. Mol. Biol. 345 (2): 211?227.

Application Notes

• Application Notes: Categories: Peptides. Ship 1 : -20 C or below