Caspase 1 (ICE) Substrate, fluorogenic

Product Overview

• Article Name: Caspase 1 (ICE) Substrate, fluorogenic
• Biozol Catalog Number: ECH-860-17
• Supplier Catalog Number: 860-17
• Alternative Catalog Number: ECH-860-17-25MG,ECH-860-17-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 219137-85-6 Molecular Weight: 719.24 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Tyr-Val-Ala-Asp-AFC Sequence (1-letter): Ac-YVAD-AFC Storage: -20 ?C or below Solubility: DMSO, 10 mg/mL Ac-YVAD-AFC is a fluorogenic substrate for caspase-1 and caspase-4. Reactions are monitored by measuring an increase in fluorescence signal due to AFC cleavage. The excitation and emission maxima for AFC are 400 nm and 505 nm, respectively.

References

1. Deveraux, Q.L. et al. (1997) ?X-linked IAP is a direct inhibitor of cell-death proteases? Nature 388: 300-304. 2. Wang, X. et al. (2003) ?Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntingtons disease? Proc. Natl. Acad. Sci. USA 100 (18): 10483?10487.

Application Notes

• Application Notes: Categories: Peptides. Related: Caspase, Enzyme Substrates. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature