Ac-Asp-Glu-Val-Asp-pNA (Caspase-3 (Apopain) Substrate), CAS [[189950-66-1]]

Product Overview

• Article Name: Ac-Asp-Glu-Val-Asp-pNA (Caspase-3 (Apopain) Substrate), CAS [[189950-66-1]]
• Biozol Catalog Number: ECH-860-20-25MG
• Supplier Catalog Number: 860-20-25mg
• Alternative Catalog Number: ECH-860-20-25MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 189950-66-1Molecular Weight: 638.22Salt Form: TFAPurity: >96%Sequence (3-letter): Ac-Asp-Glu-Val-Asp-pNASequence (1-letter): Ac-DEVD-pNAStorage: -20 AC or belowSolubility: DMSO and acetonitrile:methanol (1:1) to 1 mg/mlCaspase-3 (Apopain) Substrate is a colorimetric substrate for caspase-3 with the sequence Ac-DEVD-pNA. Caspase-3 is a protease that is rapidly activated during apoptosis and that cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Cleavage of Ac-DEVD-pNA is monitored by measuring absorbance at 405 nm. Ac-DEVD-pNA is poorly cleaved by caspase-2.Km = 18 iM (Casp-1) 11 iM (Casp-3) 32 iM (Casp-4) 180 iM (Casp-6) 12 iM (Casp-7)References1. Talanian R.V. et al. (1997) a€Substrate Specificities of Caspase Family Proteasesa€ J. Biol. Chem. 272 (15): 9677a€''9682.2.Nagane M. et al. (1998) a€Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteasesa€ Proc. Natl. Acad. Sci. USA 95 (10): 5724a€''5729.

Product Properties

• Tag: 1276 1277 1279 1208 1278 1179
• CAS Number: [189950-66-1]