Ac-Val-Asp-Val-Ala-Asp-pNA (Caspase 2 (ICH-1) Substrate), CAS [[189684-53-5]]

Product Overview

• Article Name: Ac-Val-Asp-Val-Ala-Asp-pNA (Caspase 2 (ICH-1) Substrate), CAS [[189684-53-5]]
• Biozol Catalog Number: ECH-860-46-25MG
• Supplier Catalog Number: 860-46-25mg
• Alternative Catalog Number: ECH-860-46-25MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 189684-53-5 Molecular Weight: 679.28 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Val-Asp-Val-Ala-Asp-pNA Sequence (1-letter): Ac-VDVAD-pNA Storage: -20 AC or belowAc-Val-Asp-Val-Ala-Asp-pNA is a chromogenic substrate for Caspase 2. Caspase 2 part of the ICH-1 sub-family is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP) RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD) and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis. Caspase-2 cleaves at an Asp residue with a preferred sequence of Val-Asp-Val-Ala-Asp-X.Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.

Product Properties

• Tag: 1208 1179
• CAS Number: [189684-53-5]