Caspase 8 Substrate, colorimetric

Product Overview

• Article Name: Caspase 8 Substrate, colorimetric
• Biozol Catalog Number: ECH-860-56
• Supplier Catalog Number: 860-56
• Alternative Catalog Number: ECH-860-56-25MG,ECH-860-56-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 219138-21-3 Molecular Weight: 638.26 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Ile-Glu-Thr-Asp-pNA Sequence (1-letter): Ac-IETD-pNA Storage: -20 ?C or below Solubility: DMSO Ac-IETD-pNA is a substrate for caspase-8 and granzyme B. Caspases are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Caspase-8 is an attractive therapeutic target for a variety of degenerative disorders. The absorbance maximum for the cleaved pNA is at 405 nm.

References

1. N.A.Thornberry et al., (1997) ?A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis? J. Biol. Chem. 272: 17907. 2. Watt, W. et al. (1999) ?The atomic-resolution structure of human caspase-8, a key activator of apoptosis? Structure 7 (9): 1135?1143.

Application Notes

• Application Notes: Categories: Peptides. Related: Caspase, Enzyme Substrates. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature