Ac-Trp-Val-Ala-Asp-AMC (Caspase 1 (ICE) Substrate), CAS [[189275-74-9]]

Product Overview

• Article Name: Ac-Trp-Val-Ala-Asp-AMC (Caspase 1 (ICE) Substrate), CAS [[189275-74-9]]
• Biozol Catalog Number: ECH-860-64-5MG
• Supplier Catalog Number: 860-64-5mg
• Alternative Catalog Number: ECH-860-64-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 189275-74-9 Molecular Weight: 688.29 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Trp-Val-Ala-Asp-AMC Sequence (1-letter): Ac-WVAD-AMC Storage: -20 AC or belowAc-Trp-Val-Ala-Asp-AMC is a fluorogenic substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein which is a potent inhibitor of apoptosis inhibits activation of these proteases in BRK cells.Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

Product Properties

• Tag: 1208 1179
• CAS Number: [189275-74-9]