Molecular Weight: 651.27 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Trp-Val-Ala-Asp-pNA Sequence (1-letter): Ac-WVAD-pNA Storage: -20 AC or belowAc-Trp-Val-Ala-Asp-pNA is a colorimetric substrate of Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein which is a potent inhibitor of apoptosis inhibits activation of these proteases in BRK cells.Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.
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1208 1179
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