Molecular Weight: 730.24 Salt Form: N/A Purity: >96% Sequence (3-letter): Z-Asp-Glu-Val-Asp-pNA Sequence (1-letter): Z-DEVD-pNA Storage: -20 AC or belowZ-Asp-Glu-Val-Asp-pNA is a colorimetric substrate for Caspase 3 a cysteine protease that is rapidly activated during apoptosis and cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimera€(TM)s disease and proposed as a target for drug discovery.Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.
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1208 1179
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