Z-Asp-Glu-Val-Asp-AFC (Caspase 3 (Apopain) Substrate), CAS [[219138-06-4]]

Product Overview

• Article Name: Z-Asp-Glu-Val-Asp-AFC (Caspase 3 (Apopain) Substrate), CAS [[219138-06-4]]
• Biozol Catalog Number: ECH-863-18-5MG
• Supplier Catalog Number: 863-18-5mg
• Alternative Catalog Number: ECH-863-18-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 219138-06-4 Molecular Weight: 821.24 Salt Form: N/A Purity: >96% Sequence (3-letter): Z-Asp-Glu-Val-Asp-AFC Sequence (1-letter): Z-DEVD-AFC Storage: -20 AC or belowZ-Asp-Glu-Val-Asp-AFC is a fluorogenic substrate for caspase 3. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimera€(TM)s disease and proposed as a target for drug discovery.Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

Product Properties

• Tag: 1208 1179
• CAS Number: [219138-06-4]