Z-Val-Asp-Val-Ala-Asp-AFC (Caspase 2 (ICH-1) Substrate), CAS [[219138-08-6]]

Product Overview

• Article Name: Z-Val-Asp-Val-Ala-Asp-AFC (Caspase 2 (ICH-1) Substrate), CAS [[219138-08-6]]
• Biozol Catalog Number: ECH-863-49-5MG
• Supplier Catalog Number: 863-49-5mg
• Alternative Catalog Number: ECH-863-49-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

CAS Number: 219138-08-6 Molecular Weight: 862.3 Salt Form: N/A Purity: >96% Sequence (3-letter): Z-Val-Asp-Val-Ala-Asp-AFC Sequence (1-letter): Z-VDVAD-AFC Storage: -20 AC or belowZ-VDVAD-AFC is a fluorogenic substrate for caspase 2. Caspase 2 part of the ICH-1 sub-family is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP) RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD) and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis. Caspase-2 cleaves at an Asp residue with a preferred sequence of Val-Asp-Val-Ala-Asp-X.Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

Product Properties

• Tag: 1208 1179
• CAS Number: [219138-08-6]