CAS Number: 124485-41-2Molecular Weight: 717.75Salt Form: TFAPurity: >95%Sequence (3-letter): Z-Val-Val-Arg-AFCSequence (1-letter): Z-VVR-AFCStorage: -20 AC or belowZ-Val-Val-Arg-AFC is a fluorogenic substrate for cathepsin S a lysosomal cysteine protease with important roles in MHC Class II antigen presentation and nociception. Cathepsin S also cleaves several extracellular matrix proteins (laminin fibronectin elastin osteocalcin) and glycosaminoglycans (heparin sulfate chondroitin sulfate).Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.
Tag:
1179
CAS Number:
[124485-41-2]
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