Autocamtide-2 Related Inhibitory Peptide, myristoylated

Product Overview

• Article Name: Autocamtide-2 Related Inhibitory Peptide, myristoylated
• Biozol Catalog Number: ECH-891-26
• Supplier Catalog Number: 891-26
• Alternative Catalog Number: ECH-891-26-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Molecular Weight: 1707.08 Salt Form: TFA Purity: >96% Sequence (3-letter): Myristoyl-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH Sequence (1-letter): (Myristoyl)KKALRRQEAVDAL-OH Storage: -20 ?C or below Autocamtide-2 Related Inhibitory Peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that contains the autophosphorylation site (Thr286/Thr287) found within the autoinhibitory domain of the protein kinase. It is nonphosphorylatable and selective for CaMKII over other protein kinases such as PKC and PKA and is not capable of being phosphorylated. This compound is a used to study the physiological roles of CaMKII. The myristoyl modification allows for cell permeability.

References

Ishida, A., Kameshita, I., Okuno, S.,?et al. (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.?Biochemical and Biophysical Research Communications?212(3),?806-812

Application Notes

• Application Notes: Categories: Peptides. Related: Inhibitor. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature