Resveratrol is a class IA PI3K inhibitor, activates SIRT1, and displays antiproliferative effect on human breast epithelial cells. By depolarization of mitochondrial membrane and caspase-9 activation resveratrol induces apoptosis. In addition, Resveratrol inhibits ribonucleotide reductase and DNA synthesis, cyclooxygenase-1, PKD, and eicosanoid synthesis.
