Sphingosine Kinase Inhibitor (SKI-II)

Product Overview

• Article Name: Sphingosine Kinase Inhibitor (SKI-II)
• Biozol Catalog Number: ECH-B-0024
• Supplier Catalog Number: B-0024
• Alternative Catalog Number: ECH-B-0024-10MG,ECH-B-0024-50MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 µM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCalpha at concentrations up to 60 µM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.

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Solubility

DMSO, >5 mg/mL

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Documents

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Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Inhibitor, Sphingolipid. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature